[HTML][HTML] In silico and in vitro evaluation of kaempferol as a potential inhibitor of the SARS‐CoV‐2 main protease (3CLpro)

A Khan, W Heng, Y Wang, J Qiu, X Wei… - Phytotherapy …, 2021 - ncbi.nlm.nih.gov
… and its impact on the protein's internal dynamics. To further confirm the compactness of the …
that kaempferol possesses strong anti‐coronavirus activity and thus tested against SARs‐CoV…

[HTML][HTML] Anti-viral and anti-inflammatory effects of kaempferol and quercetin and COVID-2019: A scoping review

MR Khazdair, A Anaeigoudari… - Asian Pacific Journal of …, 2021 - journals.lww.com
Kaempferol and quercetin showed antiviral properties such as inhibition of protein kinase
B and phosphorylation of protein … effects on a selective channel (3a channel) expressed in …

[HTML][HTML] Kaempferol: A review of current evidence of its antiviral potential

A Periferakis, AT Periferakis, L Troumpata… - International Journal of …, 2023 - mdpi.com
… the available research on the antiviral properties of kaempferol and its derivatives (Figure 1)
either … kaempferol glycosides were effective in blocking the 3a channels of coronaviruses in …

[HTML][HTML] Channel activity of SARS-CoV-2 viroporin ORF3a inhibited by adamantanes and phenolic plant metabolites

MS Fam, CA Sedky, NO Turky, HG Breitinger… - Scientific reports, 2023 - nature.com
coronavirus (SARS-CoV) and in 2019, a novel coronavirus of bat … as target for antiviral therapy,
and kaempferol and related … encoding ORF3a protein (3a), and ORF3a protein fused to a …

[HTML][HTML] Drug design strategies for the treatment of viral disease. Plant phenolic compounds and their derivatives

M Kowalczyk, A Golonko, R Świsłocka… - Frontiers in …, 2021 - frontiersin.org
… We believe that in the era of coronavirus pandemic, it is … The EC 50 value for the kaempferol
derivative was 7.4 μg/ml … the cation-selective channel formed by 3a protein, that may …

… of Kaempferol as viral entry inhibitor and DL-Arginine as viral replication inhibitor from selected plants of Indian traditional medicine against COVID-19: An in silico …

A Jayaprakashkamath, M Murali, B Nair… - … -Aided Drug Design, 2023 - ingentaconnect.com
… The effectiveness of kaempferol and its derivatives as agents that inhibit the 3a
Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus. Planta …

Natural products: A rich source of antiviral drug lead candidates for the management of COVID-19

YS Wijayasinghe, P Bhansali, RE Viola… - Current …, 2021 - ingentaconnect.com
… Herbacetin, a kaempferol derivative with an additional … The siRNA that suppresses viral 3a
protein expression in the host cell … Thus, compounds that can inhibit the 3a ion channel would …

[PDF][PDF] Potential therapeutic effects of some flavonoids on coronavirus disease 2019. Physiology and Pharmacology 2021; 25: 99-101

MR Khazdair - 2021 - sid.ir
… In conclusion, quercetin and kaempferol inhibited binding of viral spike protein of SARS-CoV…
Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus. …

An Overview on Flavonoids as Potential Antiviral Strategies against Coronavirus Infections.

KT Akça, İ Süntar - Gazi Medical Journal, 2020 - search.ebscohost.com
proteins in the structure of coronaviruses: the spike protein (S), … were tested according to
their potency to inhibit channel 3a. … Kaempferol derivatives with rhamnose residue were also …

[HTML][HTML] Anti-COVID-19 drug candidates: A review on potential biological activities of natural products in the management of new coronavirus infection

A Prasansuklab, A Theerasri, P Rangsinth… - … Medicine, 2021 - Elsevier
… and ion channel activity of viroporin 3a suppresses the release of viral particles from infected
… homology of the S protein RBD sequence between the beta coronaviruses SARS-CoV and …